Emandione
Emandione Brand names, Emandione Analogs
- Athrombon
- Bindan
- Cronodione
- Danedion
- Danilon
- Danilone
- Diadilan
- Dindevan
- Dineval
- Diophindane
- Emandion
- Emandione
- Eridione
- Fenhydren
- Fenilin
- Fenindion
- Hedulin
- Hemolidione
- Indema
- Indion
- Indon
- PID
- Phenhydren
- Phenillin
- Phenylen
- Phenylin
- Phenylindanedione
- Phenylindione
- Phenyline
- Phenyllin
- Pindione
- Rectadione
- Theradione
- Thrombasal
- Tromazal
- Trombol
Emandione Brand Names Mixture
- No information avaliable
Emandione Chemical_Formula
C15H10O2
Emandione RX_link
No information avaliable
Emandione fda sheet
Emandione msds (material safety sheet)
Emandione Synthesis Reference
No information avaliable
Emandione Molecular Weight
222.239 g/mol
Emandione Melting Point
148-151 oC
Emandione H2O Solubility
27 mg/L (at 20 oC)
Emandione State
Solid
Emandione LogP
2.917
Emandione Dosage Forms
Tablet
Emandione Indication
For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis.
Emandione Pharmacology
Phenindione thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver. Anticoagulants such as Phenindione have no direct effect on an established thrombus, nor do they reverse ischemic tissue damage (damage caused by an inadequate blood supply to an organ or part of the body). However, once a thrombus has occurred, the goal of anticoagulant treatment is to prevent further extension of the formed clot and prevent secondary thromboembolic complications which may result in serious and possibly fatal sequelae. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higer incidence of severe adverse effects.
Emandione Absorption
Absorbed slowly from the gastrointestinal tract.
Emandione side effects and Toxicity
Oral, mouse: LD50 = 175 mg/kg; Oral, rat: LD50 = 163 mg/kg.
Emandione Patient Information
No information avaliable
Emandione Organisms Affected
Humans and other mammals
