Phenylindione
Phenylindione Brand names, Phenylindione Analogs
- Athrombon
- Bindan
- Cronodione
- Danedion
- Danilon
- Danilone
- Diadilan
- Dindevan
- Dineval
- Diophindane
- Emandion
- Emandione
- Eridione
- Fenhydren
- Fenilin
- Fenindion
- Hedulin
- Hemolidione
- Indema
- Indion
- Indon
- PID
- Phenhydren
- Phenillin
- Phenylen
- Phenylin
- Phenylindanedione
- Phenylindione
- Phenyline
- Phenyllin
- Pindione
- Rectadione
- Theradione
- Thrombasal
- Tromazal
- Trombol
Phenylindione Brand Names Mixture
- No information avaliable
Phenylindione Chemical_Formula
C15H10O2
Phenylindione RX_link
No information avaliable
Phenylindione fda sheet
Phenylindione msds (material safety sheet)
Phenylindione Synthesis Reference
No information avaliable
Phenylindione Molecular Weight
222.239 g/mol
Phenylindione Melting Point
148-151 oC
Phenylindione H2O Solubility
27 mg/L (at 20 oC)
Phenylindione State
Solid
Phenylindione LogP
2.917
Phenylindione Dosage Forms
Tablet
Phenylindione Indication
For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis.
Phenylindione Pharmacology
Phenindione thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver. Anticoagulants such as Phenindione have no direct effect on an established thrombus, nor do they reverse ischemic tissue damage (damage caused by an inadequate blood supply to an organ or part of the body). However, once a thrombus has occurred, the goal of anticoagulant treatment is to prevent further extension of the formed clot and prevent secondary thromboembolic complications which may result in serious and possibly fatal sequelae. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higer incidence of severe adverse effects.
Phenylindione Absorption
Absorbed slowly from the gastrointestinal tract.
Phenylindione side effects and Toxicity
Oral, mouse: LD50 = 175 mg/kg; Oral, rat: LD50 = 163 mg/kg.
Phenylindione Patient Information
No information avaliable
Phenylindione Organisms Affected
Humans and other mammals
