Thrombasal
Thrombasal Brand names, Thrombasal Analogs
- Athrombon
- Bindan
- Cronodione
- Danedion
- Danilon
- Danilone
- Diadilan
- Dindevan
- Dineval
- Diophindane
- Emandion
- Emandione
- Eridione
- Fenhydren
- Fenilin
- Fenindion
- Hedulin
- Hemolidione
- Indema
- Indion
- Indon
- PID
- Phenhydren
- Phenillin
- Phenylen
- Phenylin
- Phenylindanedione
- Phenylindione
- Phenyline
- Phenyllin
- Pindione
- Rectadione
- Theradione
- Thrombasal
- Tromazal
- Trombol
Thrombasal Brand Names Mixture
- No information avaliable
Thrombasal Chemical_Formula
C15H10O2
Thrombasal RX_link
No information avaliable
Thrombasal fda sheet
Thrombasal msds (material safety sheet)
Thrombasal Synthesis Reference
No information avaliable
Thrombasal Molecular Weight
222.239 g/mol
Thrombasal Melting Point
148-151 oC
Thrombasal H2O Solubility
27 mg/L (at 20 oC)
Thrombasal State
Solid
Thrombasal LogP
2.917
Thrombasal Dosage Forms
Tablet
Thrombasal Indication
For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis.
Thrombasal Pharmacology
Phenindione thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver. Anticoagulants such as Phenindione have no direct effect on an established thrombus, nor do they reverse ischemic tissue damage (damage caused by an inadequate blood supply to an organ or part of the body). However, once a thrombus has occurred, the goal of anticoagulant treatment is to prevent further extension of the formed clot and prevent secondary thromboembolic complications which may result in serious and possibly fatal sequelae. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higer incidence of severe adverse effects.
Thrombasal Absorption
Absorbed slowly from the gastrointestinal tract.
Thrombasal side effects and Toxicity
Oral, mouse: LD50 = 175 mg/kg; Oral, rat: LD50 = 163 mg/kg.
Thrombasal Patient Information
No information avaliable
Thrombasal Organisms Affected
Humans and other mammals
