Danilon
Brand names,
Danilon
Analogs
Danilon
Brand Names Mixture
Danilon
Chemical_Formula
C15H10O2
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RX_link
No information avaliable
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
Danilon
Molecular Weight
222.239 g/mol
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Melting Point
148-151 oC
Danilon
H2O Solubility
27 mg/L (at 20 oC)
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State
Solid
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LogP
2.917
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Dosage Forms
Tablet
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Indication
For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis.
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Pharmacology
Phenindione thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver. Anticoagulants such as Phenindione have no direct effect on an established thrombus, nor do they reverse ischemic tissue damage (damage caused by an inadequate blood supply to an organ or part of the body). However, once a thrombus has occurred, the goal of anticoagulant treatment is to prevent further extension of the formed clot and prevent secondary thromboembolic complications which may result in serious and possibly fatal sequelae. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higer incidence of severe adverse effects.
Danilon
Absorption
Absorbed slowly from the gastrointestinal tract.
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side effects and Toxicity
Oral, mouse: LD50 = 175 mg/kg; Oral, rat: LD50 = 163 mg/kg.
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Patient Information
No information avaliable
Danilon
Organisms Affected
Humans and other mammals