Diophindane
Diophindane Brand names, Diophindane Analogs
- Athrombon
- Bindan
- Cronodione
- Danedion
- Danilon
- Danilone
- Diadilan
- Dindevan
- Dineval
- Diophindane
- Emandion
- Emandione
- Eridione
- Fenhydren
- Fenilin
- Fenindion
- Hedulin
- Hemolidione
- Indema
- Indion
- Indon
- PID
- Phenhydren
- Phenillin
- Phenylen
- Phenylin
- Phenylindanedione
- Phenylindione
- Phenyline
- Phenyllin
- Pindione
- Rectadione
- Theradione
- Thrombasal
- Tromazal
- Trombol
Diophindane Brand Names Mixture
- No information avaliable
Diophindane Chemical_Formula
C15H10O2
Diophindane RX_link
No information avaliable
Diophindane fda sheet
Diophindane msds (material safety sheet)
Diophindane Synthesis Reference
No information avaliable
Diophindane Molecular Weight
222.239 g/mol
Diophindane Melting Point
148-151 oC
Diophindane H2O Solubility
27 mg/L (at 20 oC)
Diophindane State
Solid
Diophindane LogP
2.917
Diophindane Dosage Forms
Tablet
Diophindane Indication
For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis.
Diophindane Pharmacology
Phenindione thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver. Anticoagulants such as Phenindione have no direct effect on an established thrombus, nor do they reverse ischemic tissue damage (damage caused by an inadequate blood supply to an organ or part of the body). However, once a thrombus has occurred, the goal of anticoagulant treatment is to prevent further extension of the formed clot and prevent secondary thromboembolic complications which may result in serious and possibly fatal sequelae. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higer incidence of severe adverse effects.
Diophindane Absorption
Absorbed slowly from the gastrointestinal tract.
Diophindane side effects and Toxicity
Oral, mouse: LD50 = 175 mg/kg; Oral, rat: LD50 = 163 mg/kg.
Diophindane Patient Information
No information avaliable
Diophindane Organisms Affected
Humans and other mammals
