Diophindane

• Anticoagulants
• ATC:B01AA02

• Athrombon
• Bindan
• Cronodione
• Danedion
• Danilon
• Danilone
• Diadilan
• Dindevan
• Dineval
• Diophindane
• Emandion
• Emandione
• Eridione
• Fenhydren
• Fenilin
• Fenindion
• Hedulin
• Hemolidione
• Indema
• Indion
• Indon
• PID
• Phenhydren
• Phenillin
• Phenylen
• Phenylin
• Phenylindanedione
• Phenylindione
• Phenyline
• Phenyllin
• Pindione
• Rectadione
• Theradione
• Thrombasal
• Tromazal
• Trombol

• No information avaliable

C₁₅H₁₀O₂

No information avaliable

Diophindane MSDS

No information avaliable

222.239 g/mol

148-151 ^oC

27 mg/L (at 20 oC)

Solid

2.917

Tablet

For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis.

Phenindione thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver. Anticoagulants such as Phenindione have no direct effect on an established thrombus, nor do they reverse ischemic tissue damage (damage caused by an inadequate blood supply to an organ or part of the body). However, once a thrombus has occurred, the goal of anticoagulant treatment is to prevent further extension of the formed clot and prevent secondary thromboembolic complications which may result in serious and possibly fatal sequelae. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higer incidence of severe adverse effects.

Absorbed slowly from the gastrointestinal tract.

Oral, mouse: LD50 = 175 mg/kg; Oral, rat: LD50 = 163 mg/kg.

No information avaliable

Humans and other mammals