Phenindione
Phenindione Brand names, Phenindione Analogs
- Athrombon
- Bindan
- Cronodione
- Danedion
- Danilon
- Danilone
- Diadilan
- Dindevan
- Dineval
- Diophindane
- Emandion
- Emandione
- Eridione
- Fenhydren
- Fenilin
- Fenindion
- Hedulin
- Hemolidione
- Indema
- Indion
- Indon
- PID
- Phenhydren
- Phenillin
- Phenylen
- Phenylin
- Phenylindanedione
- Phenylindione
- Phenyline
- Phenyllin
- Pindione
- Rectadione
- Theradione
- Thrombasal
- Tromazal
- Trombol
Phenindione Brand Names Mixture
- No information avaliable
Phenindione Chemical_Formula
C15H10O2
Phenindione RX_link
No information avaliable
Phenindione fda sheet
Phenindione msds (material safety sheet)
Phenindione Synthesis Reference
No information avaliable
Phenindione Molecular Weight
222.239 g/mol
Phenindione Melting Point
148-151 oC
Phenindione H2O Solubility
27 mg/L (at 20 oC)
Phenindione State
Solid
Phenindione LogP
2.917
Phenindione Dosage Forms
Tablet
Phenindione Indication
For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis.
Phenindione Pharmacology
Phenindione thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver. Anticoagulants such as Phenindione have no direct effect on an established thrombus, nor do they reverse ischemic tissue damage (damage caused by an inadequate blood supply to an organ or part of the body). However, once a thrombus has occurred, the goal of anticoagulant treatment is to prevent further extension of the formed clot and prevent secondary thromboembolic complications which may result in serious and possibly fatal sequelae. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higer incidence of severe adverse effects.
Phenindione Absorption
Absorbed slowly from the gastrointestinal tract.
Phenindione side effects and Toxicity
Oral, mouse: LD50 = 175 mg/kg; Oral, rat: LD50 = 163 mg/kg.
Phenindione Patient Information
No information avaliable
Phenindione Organisms Affected
Humans and other mammals
