Phenindione en es it fr

Phenindione Brand names, Phenindione Analogs

Phenindione Brand Names Mixture

  • No information avaliable

Phenindione Chemical_Formula


Phenindione RX_link

No information avaliable

Phenindione fda sheet

Phenindione msds (material safety sheet)

Phenindione MSDS

Phenindione Synthesis Reference

No information avaliable

Phenindione Molecular Weight

222.239 g/mol

Phenindione Melting Point

148-151 oC

Phenindione H2O Solubility

27 mg/L (at 20 oC)

Phenindione State


Phenindione LogP


Phenindione Dosage Forms


Phenindione Indication

For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis.

Phenindione Pharmacology

Phenindione thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver. Anticoagulants such as Phenindione have no direct effect on an established thrombus, nor do they reverse ischemic tissue damage (damage caused by an inadequate blood supply to an organ or part of the body). However, once a thrombus has occurred, the goal of anticoagulant treatment is to prevent further extension of the formed clot and prevent secondary thromboembolic complications which may result in serious and possibly fatal sequelae. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higer incidence of severe adverse effects.

Phenindione Absorption

Absorbed slowly from the gastrointestinal tract.

Phenindione side effects and Toxicity

Oral, mouse: LD50 = 175 mg/kg; Oral, rat: LD50 = 163 mg/kg.

Phenindione Patient Information

No information avaliable

Phenindione Organisms Affected

Humans and other mammals