Imipramine
Brand names,
Imipramine
Analogs
Imipramine
Brand Names Mixture
Imipramine
Chemical_Formula
C19H24N2
Imipramine
RX_link
http://www.rxlist.com/cgi/generic/imip.htm
Imipramine
fda sheet
Imipramine
msds (material safety sheet)
Imipramine
Synthesis Reference
No information avaliable
Imipramine
Molecular Weight
280.407 g/mol
Imipramine
Melting Point
174.5 oC
Imipramine
H2O Solubility
18.2 mg/L
Imipramine
State
Solid
Imipramine
LogP
4.184
Imipramine
Dosage Forms
Tablet
Imipramine
Indication
For the relief of symptoms of depression and as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older.
Imipramine
Pharmacology
Imipramine is a tricyclic antidepressant with general pharmacological properties similar to those of structurally related tricyclic antidepressant drugs such as amitriptyline and doxepin. A tertiary amine, imipramine inhibits the reuptake of serotonin more so than most secondary amine tricyclics, meaning that it blocks the reuptake of neurotransmitters serotonin and noradrenaline almost equally. It is also effective in migraine prophylaxis, but not in abortion of acute migraine attack.
Imipramine
Absorption
Rapidly and well absorbed after oral administration
Imipramine
side effects and Toxicity
Oral, rat LD50: 355 to 682 mg/kg. Toxic signs proceed progressively from depression, irregular respiration and ataxia to convulsions and death.
Imipramine
Patient Information
Imipramine
Organisms Affected
Humans and other mammals