Tofraniln A
Brand names,
Tofraniln A
Analogs
Tofraniln A
Brand Names Mixture
Tofraniln A
Chemical_Formula
C19H24N2
Tofraniln A
RX_link
http://www.rxlist.com/cgi/generic/imip.htm
Tofraniln A
fda sheet
Tofraniln A
msds (material safety sheet)
Tofraniln A
Synthesis Reference
No information avaliable
Tofraniln A
Molecular Weight
280.407 g/mol
Tofraniln A
Melting Point
174.5 oC
Tofraniln A
H2O Solubility
18.2 mg/L
Tofraniln A
State
Solid
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LogP
4.184
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Dosage Forms
Tablet
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Indication
For the relief of symptoms of depression and as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older.
Tofraniln A
Pharmacology
Imipramine is a tricyclic antidepressant with general pharmacological properties similar to those of structurally related tricyclic antidepressant drugs such as amitriptyline and doxepin. A tertiary amine, imipramine inhibits the reuptake of serotonin more so than most secondary amine tricyclics, meaning that it blocks the reuptake of neurotransmitters serotonin and noradrenaline almost equally. It is also effective in migraine prophylaxis, but not in abortion of acute migraine attack.
Tofraniln A
Absorption
Rapidly and well absorbed after oral administration
Tofraniln A
side effects and Toxicity
Oral, rat LD50: 355 to 682 mg/kg. Toxic signs proceed progressively from depression, irregular respiration and ataxia to convulsions and death.
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Patient Information
Tofraniln A
Organisms Affected
Humans and other mammals