Imipramina
Brand names,
Imipramina
Analogs
Imipramina
Brand Names Mixture
Imipramina
Chemical_Formula
C19H24N2
Imipramina
RX_link
http://www.rxlist.com/cgi/generic/imip.htm
Imipramina
fda sheet
Imipramina
msds (material safety sheet)
Imipramina
Synthesis Reference
No information avaliable
Imipramina
Molecular Weight
280.407 g/mol
Imipramina
Melting Point
174.5 oC
Imipramina
H2O Solubility
18.2 mg/L
Imipramina
State
Solid
Imipramina
LogP
4.184
Imipramina
Dosage Forms
Tablet
Imipramina
Indication
For the relief of symptoms of depression and as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older.
Imipramina
Pharmacology
Imipramine is a tricyclic antidepressant with general pharmacological properties similar to those of structurally related tricyclic antidepressant drugs such as amitriptyline and doxepin. A tertiary amine, imipramine inhibits the reuptake of serotonin more so than most secondary amine tricyclics, meaning that it blocks the reuptake of neurotransmitters serotonin and noradrenaline almost equally. It is also effective in migraine prophylaxis, but not in abortion of acute migraine attack.
Imipramina
Absorption
Rapidly and well absorbed after oral administration
Imipramina
side effects and Toxicity
Oral, rat LD50: 355 to 682 mg/kg. Toxic signs proceed progressively from depression, irregular respiration and ataxia to convulsions and death.
Imipramina
Patient Information
Imipramina
Organisms Affected
Humans and other mammals