Antideprin
Brand names,
Antideprin
Analogs
Antideprin
Brand Names Mixture
Antideprin
Chemical_Formula
C19H24N2
Antideprin
RX_link
http://www.rxlist.com/cgi/generic/imip.htm
Antideprin
fda sheet
Antideprin
msds (material safety sheet)
Antideprin
Synthesis Reference
No information avaliable
Antideprin
Molecular Weight
280.407 g/mol
Antideprin
Melting Point
174.5 oC
Antideprin
H2O Solubility
18.2 mg/L
Antideprin
State
Solid
Antideprin
LogP
4.184
Antideprin
Dosage Forms
Tablet
Antideprin
Indication
For the relief of symptoms of depression and as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older.
Antideprin
Pharmacology
Imipramine is a tricyclic antidepressant with general pharmacological properties similar to those of structurally related tricyclic antidepressant drugs such as amitriptyline and doxepin. A tertiary amine, imipramine inhibits the reuptake of serotonin more so than most secondary amine tricyclics, meaning that it blocks the reuptake of neurotransmitters serotonin and noradrenaline almost equally. It is also effective in migraine prophylaxis, but not in abortion of acute migraine attack.
Antideprin
Absorption
Rapidly and well absorbed after oral administration
Antideprin
side effects and Toxicity
Oral, rat LD50: 355 to 682 mg/kg. Toxic signs proceed progressively from depression, irregular respiration and ataxia to convulsions and death.
Antideprin
Patient Information
Antideprin
Organisms Affected
Humans and other mammals