Declomipramine
Brand names,
Declomipramine
Analogs
Declomipramine
Brand Names Mixture
Declomipramine
Chemical_Formula
C19H24N2
Declomipramine
RX_link
http://www.rxlist.com/cgi/generic/imip.htm
Declomipramine
fda sheet
Declomipramine
msds (material safety sheet)
Declomipramine
Synthesis Reference
No information avaliable
Declomipramine
Molecular Weight
280.407 g/mol
Declomipramine
Melting Point
174.5 oC
Declomipramine
H2O Solubility
18.2 mg/L
Declomipramine
State
Solid
Declomipramine
LogP
4.184
Declomipramine
Dosage Forms
Tablet
Declomipramine
Indication
For the relief of symptoms of depression and as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older.
Declomipramine
Pharmacology
Imipramine is a tricyclic antidepressant with general pharmacological properties similar to those of structurally related tricyclic antidepressant drugs such as amitriptyline and doxepin. A tertiary amine, imipramine inhibits the reuptake of serotonin more so than most secondary amine tricyclics, meaning that it blocks the reuptake of neurotransmitters serotonin and noradrenaline almost equally. It is also effective in migraine prophylaxis, but not in abortion of acute migraine attack.
Declomipramine
Absorption
Rapidly and well absorbed after oral administration
Declomipramine
side effects and Toxicity
Oral, rat LD50: 355 to 682 mg/kg. Toxic signs proceed progressively from depression, irregular respiration and ataxia to convulsions and death.
Declomipramine
Patient Information
Declomipramine
Organisms Affected
Humans and other mammals