Tofranil-Pm
Brand names,
Tofranil-Pm
Analogs
Tofranil-Pm
Brand Names Mixture
Tofranil-Pm
Chemical_Formula
C19H24N2
Tofranil-Pm
RX_link
http://www.rxlist.com/cgi/generic/imip.htm
Tofranil-Pm
fda sheet
Tofranil-Pm
msds (material safety sheet)
Tofranil-Pm
Synthesis Reference
No information avaliable
Tofranil-Pm
Molecular Weight
280.407 g/mol
Tofranil-Pm
Melting Point
174.5 oC
Tofranil-Pm
H2O Solubility
18.2 mg/L
Tofranil-Pm
State
Solid
Tofranil-Pm
LogP
4.184
Tofranil-Pm
Dosage Forms
Tablet
Tofranil-Pm
Indication
For the relief of symptoms of depression and as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older.
Tofranil-Pm
Pharmacology
Imipramine is a tricyclic antidepressant with general pharmacological properties similar to those of structurally related tricyclic antidepressant drugs such as amitriptyline and doxepin. A tertiary amine, imipramine inhibits the reuptake of serotonin more so than most secondary amine tricyclics, meaning that it blocks the reuptake of neurotransmitters serotonin and noradrenaline almost equally. It is also effective in migraine prophylaxis, but not in abortion of acute migraine attack.
Tofranil-Pm
Absorption
Rapidly and well absorbed after oral administration
Tofranil-Pm
side effects and Toxicity
Oral, rat LD50: 355 to 682 mg/kg. Toxic signs proceed progressively from depression, irregular respiration and ataxia to convulsions and death.
Tofranil-Pm
Patient Information
Tofranil-Pm
Organisms Affected
Humans and other mammals