Sk-Pramine
Brand names,
Sk-Pramine
Analogs
Sk-Pramine
Brand Names Mixture
Sk-Pramine
Chemical_Formula
C19H24N2
Sk-Pramine
RX_link
http://www.rxlist.com/cgi/generic/imip.htm
Sk-Pramine
fda sheet
Sk-Pramine
msds (material safety sheet)
Sk-Pramine
Synthesis Reference
No information avaliable
Sk-Pramine
Molecular Weight
280.407 g/mol
Sk-Pramine
Melting Point
174.5 oC
Sk-Pramine
H2O Solubility
18.2 mg/L
Sk-Pramine
State
Solid
Sk-Pramine
LogP
4.184
Sk-Pramine
Dosage Forms
Tablet
Sk-Pramine
Indication
For the relief of symptoms of depression and as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older.
Sk-Pramine
Pharmacology
Imipramine is a tricyclic antidepressant with general pharmacological properties similar to those of structurally related tricyclic antidepressant drugs such as amitriptyline and doxepin. A tertiary amine, imipramine inhibits the reuptake of serotonin more so than most secondary amine tricyclics, meaning that it blocks the reuptake of neurotransmitters serotonin and noradrenaline almost equally. It is also effective in migraine prophylaxis, but not in abortion of acute migraine attack.
Sk-Pramine
Absorption
Rapidly and well absorbed after oral administration
Sk-Pramine
side effects and Toxicity
Oral, rat LD50: 355 to 682 mg/kg. Toxic signs proceed progressively from depression, irregular respiration and ataxia to convulsions and death.
Sk-Pramine
Patient Information
Sk-Pramine
Organisms Affected
Humans and other mammals