Impramine
Brand names,
Impramine
Analogs
Impramine
Brand Names Mixture
Impramine
Chemical_Formula
C19H24N2
Impramine
RX_link
http://www.rxlist.com/cgi/generic/imip.htm
Impramine
fda sheet
Impramine
msds (material safety sheet)
Impramine
Synthesis Reference
No information avaliable
Impramine
Molecular Weight
280.407 g/mol
Impramine
Melting Point
174.5 oC
Impramine
H2O Solubility
18.2 mg/L
Impramine
State
Solid
Impramine
LogP
4.184
Impramine
Dosage Forms
Tablet
Impramine
Indication
For the relief of symptoms of depression and as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older.
Impramine
Pharmacology
Imipramine is a tricyclic antidepressant with general pharmacological properties similar to those of structurally related tricyclic antidepressant drugs such as amitriptyline and doxepin. A tertiary amine, imipramine inhibits the reuptake of serotonin more so than most secondary amine tricyclics, meaning that it blocks the reuptake of neurotransmitters serotonin and noradrenaline almost equally. It is also effective in migraine prophylaxis, but not in abortion of acute migraine attack.
Impramine
Absorption
Rapidly and well absorbed after oral administration
Impramine
side effects and Toxicity
Oral, rat LD50: 355 to 682 mg/kg. Toxic signs proceed progressively from depression, irregular respiration and ataxia to convulsions and death.
Impramine
Patient Information
Impramine
Organisms Affected
Humans and other mammals