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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C19H24N2
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RX_link
http://www.rxlist.com/cgi/generic/imip.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
280.407 g/mol
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Melting Point
174.5 oC
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H2O Solubility
18.2 mg/L
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State
Solid
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LogP
4.184
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Dosage Forms
Tablet
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Indication
For the relief of symptoms of depression and as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older.
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Pharmacology
Imipramine is a tricyclic antidepressant with general pharmacological properties similar to those of structurally related tricyclic antidepressant drugs such as amitriptyline and doxepin. A tertiary amine, imipramine inhibits the reuptake of serotonin more so than most secondary amine tricyclics, meaning that it blocks the reuptake of neurotransmitters serotonin and noradrenaline almost equally. It is also effective in migraine prophylaxis, but not in abortion of acute migraine attack.
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Absorption
Rapidly and well absorbed after oral administration
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side effects and Toxicity
Oral, rat LD50: 355 to 682 mg/kg. Toxic signs proceed progressively from depression, irregular respiration and ataxia to convulsions and death.
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Patient Information
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Organisms Affected
Humans and other mammals