Berkomine
Brand names,
Berkomine
Analogs
Berkomine
Brand Names Mixture
Berkomine
Chemical_Formula
C19H24N2
Berkomine
RX_link
http://www.rxlist.com/cgi/generic/imip.htm
Berkomine
fda sheet
Berkomine
msds (material safety sheet)
Berkomine
Synthesis Reference
No information avaliable
Berkomine
Molecular Weight
280.407 g/mol
Berkomine
Melting Point
174.5 oC
Berkomine
H2O Solubility
18.2 mg/L
Berkomine
State
Solid
Berkomine
LogP
4.184
Berkomine
Dosage Forms
Tablet
Berkomine
Indication
For the relief of symptoms of depression and as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older.
Berkomine
Pharmacology
Imipramine is a tricyclic antidepressant with general pharmacological properties similar to those of structurally related tricyclic antidepressant drugs such as amitriptyline and doxepin. A tertiary amine, imipramine inhibits the reuptake of serotonin more so than most secondary amine tricyclics, meaning that it blocks the reuptake of neurotransmitters serotonin and noradrenaline almost equally. It is also effective in migraine prophylaxis, but not in abortion of acute migraine attack.
Berkomine
Absorption
Rapidly and well absorbed after oral administration
Berkomine
side effects and Toxicity
Oral, rat LD50: 355 to 682 mg/kg. Toxic signs proceed progressively from depression, irregular respiration and ataxia to convulsions and death.
Berkomine
Patient Information
Berkomine
Organisms Affected
Humans and other mammals