Norfranil
Brand names,
Norfranil
Analogs
Norfranil
Brand Names Mixture
Norfranil
Chemical_Formula
C19H24N2
Norfranil
RX_link
http://www.rxlist.com/cgi/generic/imip.htm
Norfranil
fda sheet
Norfranil
msds (material safety sheet)
Norfranil
Synthesis Reference
No information avaliable
Norfranil
Molecular Weight
280.407 g/mol
Norfranil
Melting Point
174.5 oC
Norfranil
H2O Solubility
18.2 mg/L
Norfranil
State
Solid
Norfranil
LogP
4.184
Norfranil
Dosage Forms
Tablet
Norfranil
Indication
For the relief of symptoms of depression and as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older.
Norfranil
Pharmacology
Imipramine is a tricyclic antidepressant with general pharmacological properties similar to those of structurally related tricyclic antidepressant drugs such as amitriptyline and doxepin. A tertiary amine, imipramine inhibits the reuptake of serotonin more so than most secondary amine tricyclics, meaning that it blocks the reuptake of neurotransmitters serotonin and noradrenaline almost equally. It is also effective in migraine prophylaxis, but not in abortion of acute migraine attack.
Norfranil
Absorption
Rapidly and well absorbed after oral administration
Norfranil
side effects and Toxicity
Oral, rat LD50: 355 to 682 mg/kg. Toxic signs proceed progressively from depression, irregular respiration and ataxia to convulsions and death.
Norfranil
Patient Information
Norfranil
Organisms Affected
Humans and other mammals