Imipramine Hcl
Brand names,
Imipramine Hcl
Analogs
Imipramine Hcl
Brand Names Mixture
Imipramine Hcl
Chemical_Formula
C19H24N2
Imipramine Hcl
RX_link
http://www.rxlist.com/cgi/generic/imip.htm
Imipramine Hcl
fda sheet
Imipramine Hcl
msds (material safety sheet)
Imipramine Hcl
Synthesis Reference
No information avaliable
Imipramine Hcl
Molecular Weight
280.407 g/mol
Imipramine Hcl
Melting Point
174.5 oC
Imipramine Hcl
H2O Solubility
18.2 mg/L
Imipramine Hcl
State
Solid
Imipramine Hcl
LogP
4.184
Imipramine Hcl
Dosage Forms
Tablet
Imipramine Hcl
Indication
For the relief of symptoms of depression and as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older.
Imipramine Hcl
Pharmacology
Imipramine is a tricyclic antidepressant with general pharmacological properties similar to those of structurally related tricyclic antidepressant drugs such as amitriptyline and doxepin. A tertiary amine, imipramine inhibits the reuptake of serotonin more so than most secondary amine tricyclics, meaning that it blocks the reuptake of neurotransmitters serotonin and noradrenaline almost equally. It is also effective in migraine prophylaxis, but not in abortion of acute migraine attack.
Imipramine Hcl
Absorption
Rapidly and well absorbed after oral administration
Imipramine Hcl
side effects and Toxicity
Oral, rat LD50: 355 to 682 mg/kg. Toxic signs proceed progressively from depression, irregular respiration and ataxia to convulsions and death.
Imipramine Hcl
Patient Information
Imipramine Hcl
Organisms Affected
Humans and other mammals