Presamine
Brand names,
Presamine
Analogs
Presamine
Brand Names Mixture
Presamine
Chemical_Formula
C19H24N2
Presamine
RX_link
http://www.rxlist.com/cgi/generic/imip.htm
Presamine
fda sheet
Presamine
msds (material safety sheet)
Presamine
Synthesis Reference
No information avaliable
Presamine
Molecular Weight
280.407 g/mol
Presamine
Melting Point
174.5 oC
Presamine
H2O Solubility
18.2 mg/L
Presamine
State
Solid
Presamine
LogP
4.184
Presamine
Dosage Forms
Tablet
Presamine
Indication
For the relief of symptoms of depression and as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older.
Presamine
Pharmacology
Imipramine is a tricyclic antidepressant with general pharmacological properties similar to those of structurally related tricyclic antidepressant drugs such as amitriptyline and doxepin. A tertiary amine, imipramine inhibits the reuptake of serotonin more so than most secondary amine tricyclics, meaning that it blocks the reuptake of neurotransmitters serotonin and noradrenaline almost equally. It is also effective in migraine prophylaxis, but not in abortion of acute migraine attack.
Presamine
Absorption
Rapidly and well absorbed after oral administration
Presamine
side effects and Toxicity
Oral, rat LD50: 355 to 682 mg/kg. Toxic signs proceed progressively from depression, irregular respiration and ataxia to convulsions and death.
Presamine
Patient Information
Presamine
Organisms Affected
Humans and other mammals