Promiben
Brand names,
Promiben
Analogs
Promiben
Brand Names Mixture
Promiben
Chemical_Formula
C19H24N2
Promiben
RX_link
http://www.rxlist.com/cgi/generic/imip.htm
Promiben
fda sheet
Promiben
msds (material safety sheet)
Promiben
Synthesis Reference
No information avaliable
Promiben
Molecular Weight
280.407 g/mol
Promiben
Melting Point
174.5 oC
Promiben
H2O Solubility
18.2 mg/L
Promiben
State
Solid
Promiben
LogP
4.184
Promiben
Dosage Forms
Tablet
Promiben
Indication
For the relief of symptoms of depression and as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older.
Promiben
Pharmacology
Imipramine is a tricyclic antidepressant with general pharmacological properties similar to those of structurally related tricyclic antidepressant drugs such as amitriptyline and doxepin. A tertiary amine, imipramine inhibits the reuptake of serotonin more so than most secondary amine tricyclics, meaning that it blocks the reuptake of neurotransmitters serotonin and noradrenaline almost equally. It is also effective in migraine prophylaxis, but not in abortion of acute migraine attack.
Promiben
Absorption
Rapidly and well absorbed after oral administration
Promiben
side effects and Toxicity
Oral, rat LD50: 355 to 682 mg/kg. Toxic signs proceed progressively from depression, irregular respiration and ataxia to convulsions and death.
Promiben
Patient Information
Promiben
Organisms Affected
Humans and other mammals