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Apo-Imipramine Brand names, Apo-Imipramine Analogs

Apo-Imipramine Brand Names Mixture

  • No information avaliable

Apo-Imipramine Chemical_Formula


Apo-Imipramine RX_link

No information avaliable

Apo-Imipramine fda sheet

Apo-Imipramine msds (material safety sheet)

Apo-Imipramine Synthesis Reference

Engelhardt, Christy Belg. pat. 617,967, C.A. 59, 517f (1963)

Apo-Imipramine Molecular Weight

263.377 g/mol

Apo-Imipramine Melting Point

169-171 oC (Protriptyline HCl)

Apo-Imipramine H2O Solubility

1.04 mg/L

Apo-Imipramine State


Apo-Imipramine LogP


Apo-Imipramine Dosage Forms


Apo-Imipramine Indication

For the treatment of depression and obsessive-compulsive disorders.

Apo-Imipramine Pharmacology

Protriptyline is a tricyclic antidepressant. It was thought that tricylic antidepressants work by inhibiting the re-uptake of the neurotransmitters norepinephrine and serotonin by nerve cells. However, this response occurs immediately, yet mood does not lift for around two weeks. It is now thought that changes occur in receptor sensitivity in the cerebral cortex and hippocampus. The hippocampus is part of the limbic system, a part of the brain involved in emotions. Presynaptic receptors are affected: a1 and b1 receptors are sensitized, a2 receptors are desensitised (leading to increased noradrenaline production). Tricyclics are also known as effective analgesics for different types of pain, especially neuropathic or neuralgic pain. A precise mechanism for their analgesic action is unknown, but it is thought that they modulate anti-pain opioid systems in the CNS via an indirect serotonergic route. They are also effective in migraine prophylaxis, but not in abortion of acute migraine attack. The mechanism of their anti-migraine action is also thought to be serotonergic.

Apo-Imipramine Absorption

No information avaliable

Apo-Imipramine side effects and Toxicity

Side effects include anxiety, blood disorders, confusion, decreased libido, dizziness, flushing, headache, impotence, insomnia, low blood pressure, nightmares, rapid or irregular heartbeat, rash, seizures, sensitivity to sunlight, stomach and intestinal problems.

Apo-Imipramine Patient Information


Protriptyline is used to treat the symptoms of mental depression in people who are under close medical supervision. It is particularly suitable for those who are inactive and withdrawn.

Protriptyline is a tricyclic antidepressants. Unlike the class of antidepressants known as monoamine oxidase (MAO) inhibitors, it does not act primarily through stimulation of the central nervous system. It tends to work more rapidly than some other tricyclic antidepressants. Improvement sometimes begins within a week.

If you are prone to anxiety or agitation, Protriptyline can make the problem worse. It can also exaggerate the symptoms of manic-depression and schizophrenia.

Protriptyline must never be taken with drugs classified as monoamine oxidase (MAO) inhibitors, such as the antidepressants Nardil and Parnate.

Protriptyline should be used with caution by people who have heart problems or a thyroid disorder.

Take precaution if you have a history of seizures, difficulty urinating, or glaucoma (high pressure in the eyes); or use alcohol excessively while taking Protriptyline.

Apo-Imipramine Organisms Affected

Humans and other mammals