Melipramine
Brand names,
Melipramine
Analogs
Melipramine
Brand Names Mixture
Melipramine
Chemical_Formula
C19H24N2
Melipramine
RX_link
http://www.rxlist.com/cgi/generic/imip.htm
Melipramine
fda sheet
Melipramine
msds (material safety sheet)
Melipramine
Synthesis Reference
No information avaliable
Melipramine
Molecular Weight
280.407 g/mol
Melipramine
Melting Point
174.5 oC
Melipramine
H2O Solubility
18.2 mg/L
Melipramine
State
Solid
Melipramine
LogP
4.184
Melipramine
Dosage Forms
Tablet
Melipramine
Indication
For the relief of symptoms of depression and as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older.
Melipramine
Pharmacology
Imipramine is a tricyclic antidepressant with general pharmacological properties similar to those of structurally related tricyclic antidepressant drugs such as amitriptyline and doxepin. A tertiary amine, imipramine inhibits the reuptake of serotonin more so than most secondary amine tricyclics, meaning that it blocks the reuptake of neurotransmitters serotonin and noradrenaline almost equally. It is also effective in migraine prophylaxis, but not in abortion of acute migraine attack.
Melipramine
Absorption
Rapidly and well absorbed after oral administration
Melipramine
side effects and Toxicity
Oral, rat LD50: 355 to 682 mg/kg. Toxic signs proceed progressively from depression, irregular respiration and ataxia to convulsions and death.
Melipramine
Patient Information
Melipramine
Organisms Affected
Humans and other mammals