Valergine
Category
Valergine Brand names, Valergine Analogs
Valergine Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Valergine Chemical_Formula
C17H20N2S
Valergine RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Valergine fda sheet
Valergine msds (material safety sheet)
Valergine Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Valergine Molecular Weight
284.42 g/mol
Valergine Melting Point
60oC
Valergine H2O Solubility
Freely soluble
Valergine State
Solid
Valergine LogP
4.946
Valergine Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Valergine Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Valergine Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Valergine Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Valergine side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Valergine Patient Information
Valergine Organisms Affected
Humans and other mammals
