Lergigan
Category
Lergigan Brand names, Lergigan Analogs
Lergigan Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Lergigan Chemical_Formula
C17H20N2S
Lergigan RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Lergigan fda sheet
Lergigan msds (material safety sheet)
Lergigan Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Lergigan Molecular Weight
284.42 g/mol
Lergigan Melting Point
60oC
Lergigan H2O Solubility
Freely soluble
Lergigan State
Solid
Lergigan LogP
4.946
Lergigan Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Lergigan Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Lergigan Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Lergigan Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Lergigan side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Lergigan Patient Information
Lergigan Organisms Affected
Humans and other mammals
