Promethazin
Category
Promethazin Brand names, Promethazin Analogs
Promethazin Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Promethazin Chemical_Formula
C17H20N2S
Promethazin RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Promethazin fda sheet
Promethazin msds (material safety sheet)
Promethazin Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Promethazin Molecular Weight
284.42 g/mol
Promethazin Melting Point
60oC
Promethazin H2O Solubility
Freely soluble
Promethazin State
Solid
Promethazin LogP
4.946
Promethazin Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Promethazin Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Promethazin Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Promethazin Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Promethazin side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Promethazin Patient Information
Promethazin Organisms Affected
Humans and other mammals
