Tanidil
Category
Tanidil Brand names, Tanidil Analogs
Tanidil Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Tanidil Chemical_Formula
C17H20N2S
Tanidil RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Tanidil fda sheet
Tanidil msds (material safety sheet)
Tanidil Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Tanidil Molecular Weight
284.42 g/mol
Tanidil Melting Point
60oC
Tanidil H2O Solubility
Freely soluble
Tanidil State
Solid
Tanidil LogP
4.946
Tanidil Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Tanidil Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Tanidil Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Tanidil Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Tanidil side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Tanidil Patient Information
Tanidil Organisms Affected
Humans and other mammals
