Romergan
Category
Romergan Brand names, Romergan Analogs
Romergan Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Romergan Chemical_Formula
C17H20N2S
Romergan RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Romergan fda sheet
Romergan msds (material safety sheet)
Romergan Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Romergan Molecular Weight
284.42 g/mol
Romergan Melting Point
60oC
Romergan H2O Solubility
Freely soluble
Romergan State
Solid
Romergan LogP
4.946
Romergan Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Romergan Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Romergan Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Romergan Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Romergan side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Romergan Patient Information
Romergan Organisms Affected
Humans and other mammals
