Pipolphen
Category
Pipolphen Brand names, Pipolphen Analogs
Pipolphen Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Pipolphen Chemical_Formula
C17H20N2S
Pipolphen RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Pipolphen fda sheet
Pipolphen msds (material safety sheet)
Pipolphen Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Pipolphen Molecular Weight
284.42 g/mol
Pipolphen Melting Point
60oC
Pipolphen H2O Solubility
Freely soluble
Pipolphen State
Solid
Pipolphen LogP
4.946
Pipolphen Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Pipolphen Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Pipolphen Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Pipolphen Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Pipolphen side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Pipolphen Patient Information
Pipolphen Organisms Affected
Humans and other mammals
