Diphergan
Category
Diphergan Brand names, Diphergan Analogs
Diphergan Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Diphergan Chemical_Formula
C17H20N2S
Diphergan RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Diphergan fda sheet
Diphergan msds (material safety sheet)
Diphergan Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Diphergan Molecular Weight
284.42 g/mol
Diphergan Melting Point
60oC
Diphergan H2O Solubility
Freely soluble
Diphergan State
Solid
Diphergan LogP
4.946
Diphergan Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Diphergan Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Diphergan Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Diphergan Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Diphergan side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Diphergan Patient Information
Diphergan Organisms Affected
Humans and other mammals
