Promethiazine
Category
Promethiazine Brand names, Promethiazine Analogs
Promethiazine Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Promethiazine Chemical_Formula
C17H20N2S
Promethiazine RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Promethiazine fda sheet
Promethiazine msds (material safety sheet)
Promethiazine Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Promethiazine Molecular Weight
284.42 g/mol
Promethiazine Melting Point
60oC
Promethiazine H2O Solubility
Freely soluble
Promethiazine State
Solid
Promethiazine LogP
4.946
Promethiazine Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Promethiazine Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Promethiazine Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Promethiazine Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Promethiazine side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Promethiazine Patient Information
Promethiazine Organisms Affected
Humans and other mammals
