Phenergan
Category
Phenergan Brand names, Phenergan Analogs
Phenergan Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Phenergan Chemical_Formula
C17H20N2S
Phenergan RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Phenergan fda sheet
Phenergan msds (material safety sheet)
Phenergan Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Phenergan Molecular Weight
284.42 g/mol
Phenergan Melting Point
60oC
Phenergan H2O Solubility
Freely soluble
Phenergan State
Solid
Phenergan LogP
4.946
Phenergan Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Phenergan Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Phenergan Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Phenergan Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Phenergan side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Phenergan Patient Information
Phenergan Organisms Affected
Humans and other mammals
