Atosil
Category
Atosil Brand names, Atosil Analogs
Atosil Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Atosil Chemical_Formula
C17H20N2S
Atosil RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Atosil fda sheet
Atosil msds (material safety sheet)
Atosil Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Atosil Molecular Weight
284.42 g/mol
Atosil Melting Point
60oC
Atosil H2O Solubility
Freely soluble
Atosil State
Solid
Atosil LogP
4.946
Atosil Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Atosil Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Atosil Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Atosil Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Atosil side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Atosil Patient Information
Atosil Organisms Affected
Humans and other mammals
