Prothazine
Category
Prothazine Brand names, Prothazine Analogs
Prothazine Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Prothazine Chemical_Formula
C17H20N2S
Prothazine RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Prothazine fda sheet
Prothazine msds (material safety sheet)
Prothazine Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Prothazine Molecular Weight
284.42 g/mol
Prothazine Melting Point
60oC
Prothazine H2O Solubility
Freely soluble
Prothazine State
Solid
Prothazine LogP
4.946
Prothazine Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Prothazine Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Prothazine Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Prothazine Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Prothazine side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Prothazine Patient Information
Prothazine Organisms Affected
Humans and other mammals
