Duplamin
Category
Duplamin Brand names, Duplamin Analogs
Duplamin Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Duplamin Chemical_Formula
C17H20N2S
Duplamin RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Duplamin fda sheet
Duplamin msds (material safety sheet)
Duplamin Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Duplamin Molecular Weight
284.42 g/mol
Duplamin Melting Point
60oC
Duplamin H2O Solubility
Freely soluble
Duplamin State
Solid
Duplamin LogP
4.946
Duplamin Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Duplamin Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Duplamin Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Duplamin Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Duplamin side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Duplamin Patient Information
Duplamin Organisms Affected
Humans and other mammals
