Genphen
Category
Genphen Brand names, Genphen Analogs
Genphen Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Genphen Chemical_Formula
C17H20N2S
Genphen RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Genphen fda sheet
Genphen msds (material safety sheet)
Genphen Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Genphen Molecular Weight
284.42 g/mol
Genphen Melting Point
60oC
Genphen H2O Solubility
Freely soluble
Genphen State
Solid
Genphen LogP
4.946
Genphen Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Genphen Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Genphen Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Genphen Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Genphen side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Genphen Patient Information
Genphen Organisms Affected
Humans and other mammals
