Phensedyl
Category
Phensedyl Brand names, Phensedyl Analogs
Phensedyl Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Phensedyl Chemical_Formula
C17H20N2S
Phensedyl RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Phensedyl fda sheet
Phensedyl msds (material safety sheet)
Phensedyl Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Phensedyl Molecular Weight
284.42 g/mol
Phensedyl Melting Point
60oC
Phensedyl H2O Solubility
Freely soluble
Phensedyl State
Solid
Phensedyl LogP
4.946
Phensedyl Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Phensedyl Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Phensedyl Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Phensedyl Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Phensedyl side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Phensedyl Patient Information
Phensedyl Organisms Affected
Humans and other mammals
