Proazaimine
Category
Proazaimine Brand names, Proazaimine Analogs
Proazaimine Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Proazaimine Chemical_Formula
C17H20N2S
Proazaimine RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Proazaimine fda sheet
Proazaimine msds (material safety sheet)
Proazaimine Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Proazaimine Molecular Weight
284.42 g/mol
Proazaimine Melting Point
60oC
Proazaimine H2O Solubility
Freely soluble
Proazaimine State
Solid
Proazaimine LogP
4.946
Proazaimine Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Proazaimine Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Proazaimine Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Proazaimine Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Proazaimine side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Proazaimine Patient Information
Proazaimine Organisms Affected
Humans and other mammals
