Pyrethiazine
Category
Pyrethiazine Brand names, Pyrethiazine Analogs
Pyrethiazine Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Pyrethiazine Chemical_Formula
C17H20N2S
Pyrethiazine RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Pyrethiazine fda sheet
Pyrethiazine msds (material safety sheet)
Pyrethiazine Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Pyrethiazine Molecular Weight
284.42 g/mol
Pyrethiazine Melting Point
60oC
Pyrethiazine H2O Solubility
Freely soluble
Pyrethiazine State
Solid
Pyrethiazine LogP
4.946
Pyrethiazine Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Pyrethiazine Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Pyrethiazine Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Pyrethiazine Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Pyrethiazine side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Pyrethiazine Patient Information
Pyrethiazine Organisms Affected
Humans and other mammals
