Phenargan
Category
Phenargan Brand names, Phenargan Analogs
Phenargan Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Phenargan Chemical_Formula
C17H20N2S
Phenargan RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Phenargan fda sheet
Phenargan msds (material safety sheet)
Phenargan Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Phenargan Molecular Weight
284.42 g/mol
Phenargan Melting Point
60oC
Phenargan H2O Solubility
Freely soluble
Phenargan State
Solid
Phenargan LogP
4.946
Phenargan Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Phenargan Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Phenargan Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Phenargan Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Phenargan side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Phenargan Patient Information
Phenargan Organisms Affected
Humans and other mammals
