Remsed
Category
Remsed Brand names, Remsed Analogs
Remsed Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Remsed Chemical_Formula
C17H20N2S
Remsed RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Remsed fda sheet
Remsed msds (material safety sheet)
Remsed Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Remsed Molecular Weight
284.42 g/mol
Remsed Melting Point
60oC
Remsed H2O Solubility
Freely soluble
Remsed State
Solid
Remsed LogP
4.946
Remsed Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Remsed Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Remsed Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Remsed Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Remsed side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Remsed Patient Information
Remsed Organisms Affected
Humans and other mammals
