Prorex
Category
Prorex Brand names, Prorex Analogs
Prorex Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Prorex Chemical_Formula
C17H20N2S
Prorex RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Prorex fda sheet
Prorex msds (material safety sheet)
Prorex Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Prorex Molecular Weight
284.42 g/mol
Prorex Melting Point
60oC
Prorex H2O Solubility
Freely soluble
Prorex State
Solid
Prorex LogP
4.946
Prorex Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Prorex Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Prorex Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Prorex Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Prorex side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Prorex Patient Information
Prorex Organisms Affected
Humans and other mammals
