Prometh Plain
Category
Prometh Plain Brand names, Prometh Plain Analogs
Prometh Plain Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Prometh Plain Chemical_Formula
C17H20N2S
Prometh Plain RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Prometh Plain fda sheet
Prometh Plain msds (material safety sheet)
Prometh Plain Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Prometh Plain Molecular Weight
284.42 g/mol
Prometh Plain Melting Point
60oC
Prometh Plain H2O Solubility
Freely soluble
Prometh Plain State
Solid
Prometh Plain LogP
4.946
Prometh Plain Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Prometh Plain Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Prometh Plain Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Prometh Plain Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Prometh Plain side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Prometh Plain Patient Information
Prometh Plain Organisms Affected
Humans and other mammals
