Lilly 1516
Category
Lilly 1516 Brand names, Lilly 1516 Analogs
Lilly 1516 Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Lilly 1516 Chemical_Formula
C17H20N2S
Lilly 1516 RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Lilly 1516 fda sheet
Lilly 1516 msds (material safety sheet)
Lilly 1516 Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Lilly 1516 Molecular Weight
284.42 g/mol
Lilly 1516 Melting Point
60oC
Lilly 1516 H2O Solubility
Freely soluble
Lilly 1516 State
Solid
Lilly 1516 LogP
4.946
Lilly 1516 Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Lilly 1516 Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Lilly 1516 Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Lilly 1516 Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Lilly 1516 side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Lilly 1516 Patient Information
Lilly 1516 Organisms Affected
Humans and other mammals
