Pilpophen Brand names, Pilpophen Analogs
Pilpophen Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Pilpophen fda sheet
Pilpophen msds (material safety sheet)
Pilpophen Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Pilpophen Molecular Weight
Pilpophen Melting Point
Pilpophen H2O Solubility
Pilpophen Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
For the treatment of allergic disorders, itching, nausea and vomiting.
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Pilpophen side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Pilpophen Patient Information
Pilpophen Organisms Affected
Humans and other mammals