Aprobit
Category
Aprobit Brand names, Aprobit Analogs
Aprobit Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Aprobit Chemical_Formula
C17H20N2S
Aprobit RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Aprobit fda sheet
Aprobit msds (material safety sheet)
Aprobit Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Aprobit Molecular Weight
284.42 g/mol
Aprobit Melting Point
60oC
Aprobit H2O Solubility
Freely soluble
Aprobit State
Solid
Aprobit LogP
4.946
Aprobit Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Aprobit Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Aprobit Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Aprobit Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Aprobit side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Aprobit Patient Information
Aprobit Organisms Affected
Humans and other mammals
