Iergigan
Category
Iergigan Brand names, Iergigan Analogs
Iergigan Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Iergigan Chemical_Formula
C17H20N2S
Iergigan RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Iergigan fda sheet
Iergigan msds (material safety sheet)
Iergigan Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Iergigan Molecular Weight
284.42 g/mol
Iergigan Melting Point
60oC
Iergigan H2O Solubility
Freely soluble
Iergigan State
Solid
Iergigan LogP
4.946
Iergigan Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Iergigan Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Iergigan Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Iergigan Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Iergigan side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Iergigan Patient Information
Iergigan Organisms Affected
Humans and other mammals
