Lercigan
Category
Lercigan Brand names, Lercigan Analogs
Lercigan Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Lercigan Chemical_Formula
C17H20N2S
Lercigan RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Lercigan fda sheet
Lercigan msds (material safety sheet)
Lercigan Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Lercigan Molecular Weight
284.42 g/mol
Lercigan Melting Point
60oC
Lercigan H2O Solubility
Freely soluble
Lercigan State
Solid
Lercigan LogP
4.946
Lercigan Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Lercigan Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Lercigan Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Lercigan Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Lercigan side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Lercigan Patient Information
Lercigan Organisms Affected
Humans and other mammals
