Proazamine
Category
Proazamine Brand names, Proazamine Analogs
Proazamine Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Proazamine Chemical_Formula
C17H20N2S
Proazamine RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Proazamine fda sheet
Proazamine msds (material safety sheet)
Proazamine Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Proazamine Molecular Weight
284.42 g/mol
Proazamine Melting Point
60oC
Proazamine H2O Solubility
Freely soluble
Proazamine State
Solid
Proazamine LogP
4.946
Proazamine Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Proazamine Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Proazamine Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Proazamine Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Proazamine side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Proazamine Patient Information
Proazamine Organisms Affected
Humans and other mammals
