Pyrethia Brand names, Pyrethia Analogs
Pyrethia Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Pyrethia fda sheet
Pyrethia msds (material safety sheet)
Pyrethia Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Pyrethia Molecular Weight
Pyrethia Melting Point
Pyrethia H2O Solubility
Pyrethia Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
For the treatment of allergic disorders, itching, nausea and vomiting.
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Pyrethia side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Pyrethia Patient Information
Pyrethia Organisms Affected
Humans and other mammals