Isophenergan Brand names, Isophenergan Analogs
Isophenergan Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Isophenergan fda sheet
Isophenergan msds (material safety sheet)
Isophenergan Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Isophenergan Molecular Weight
Isophenergan Melting Point
Isophenergan H2O Solubility
Isophenergan Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
For the treatment of allergic disorders, itching, nausea and vomiting.
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Isophenergan side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Isophenergan Patient Information
Isophenergan Organisms Affected
Humans and other mammals