Isophenergan
Category
Isophenergan Brand names, Isophenergan Analogs
Isophenergan Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Isophenergan Chemical_Formula
C17H20N2S
Isophenergan RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Isophenergan fda sheet
Isophenergan msds (material safety sheet)
Isophenergan Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Isophenergan Molecular Weight
284.42 g/mol
Isophenergan Melting Point
60oC
Isophenergan H2O Solubility
Freely soluble
Isophenergan State
Solid
Isophenergan LogP
4.946
Isophenergan Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Isophenergan Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Isophenergan Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Isophenergan Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Isophenergan side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Isophenergan Patient Information
Isophenergan Organisms Affected
Humans and other mammals
